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d1 receptor agonist skf 81297  (Tocris)


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    Tocris d1 receptor agonist skf 81297
    D1 Receptor Agonist Skf 81297, supplied by Tocris, used in various techniques. Bioz Stars score: 95/100, based on 163 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/d1+receptor+agonist+skf+81297+hydrobromide/SKF+81297+hydrobromide/pm30713108-228-1-10
    Average 95 stars, based on 163 article reviews
    d1 receptor agonist skf 81297 - by Bioz Stars, 2026-09
    95/100 stars

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    Article Title: Effect of Dopaminergic D1 Receptors on Plasticity Is Dependent of Serotoninergic 5-HT1A Receptors in L5-Pyramidal Neurons of the Prefrontal Cortex
    Article Snippet: The D1 Receptor agonist SKF 81297 hydrobromide (6-chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide) and the D1R antagonist SCH 23390 hydrochloride ((R)-(+)-7chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride) were from Tocris.



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    Figure 6. Changes in BLA-evoked firing induced by DA agonists and VTA stimulation. Left panelsrepresentmean SEMevokedfiringprobabilityunderbaselineconditions(whitebars) and after treatment with DA agonists/VTA stimulation (gray bars); p 0.05, difference relative to baseline. Right panels display the proportion of neurons recorded from saline- and AMPH-treated rats in which BLA-evoked firing was attenuated by these treatments. A, Treat- mentwithAMPH(0.5mg/kg,i.v.)attenuatesBLA-evokedfiringincontrols(n 9cells,9rats), but this effect was not statistically reliable in rats receiving repeated AMPH treatments (n 8 cells, 8 rats). B, Treatment with the D1 receptor agonist <t>SKF81297</t> (0.5 mg/kg, i.v.) also atten- uated BLA-evoked firing in control rats but not in AMPH-treated rats suggesting that these treatments induce a disruption in D1 receptor function (n 6 cells, 6 rats per group). C, Sup- pression of evoked-firing induced by VTA burst stimulation did not differ between saline- treated (n 6 cells, 4 rats) and AMPH-treated (n 7 cells, 7 rats) animals.
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    Figure 6. Changes in BLA-evoked firing induced by DA agonists and VTA stimulation. Left panelsrepresentmean SEMevokedfiringprobabilityunderbaselineconditions(whitebars) and after treatment with DA agonists/VTA stimulation (gray bars); p 0.05, difference relative to baseline. Right panels display the proportion of neurons recorded from saline- and AMPH-treated rats in which BLA-evoked firing was attenuated by these treatments. A, Treat- mentwithAMPH(0.5mg/kg,i.v.)attenuatesBLA-evokedfiringincontrols(n 9cells,9rats), but this effect was not statistically reliable in rats receiving repeated AMPH treatments (n 8 cells, 8 rats). B, Treatment with the D1 receptor agonist <t>SKF81297</t> (0.5 mg/kg, i.v.) also atten- uated BLA-evoked firing in control rats but not in AMPH-treated rats suggesting that these treatments induce a disruption in D1 receptor function (n 6 cells, 6 rats per group). C, Sup- pression of evoked-firing induced by VTA burst stimulation did not differ between saline- treated (n 6 cells, 4 rats) and AMPH-treated (n 7 cells, 7 rats) animals.
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    Figure 6. Changes in BLA-evoked firing induced by DA agonists and VTA stimulation. Left panelsrepresentmean SEMevokedfiringprobabilityunderbaselineconditions(whitebars) and after treatment with DA agonists/VTA stimulation (gray bars); p 0.05, difference relative to baseline. Right panels display the proportion of neurons recorded from saline- and AMPH-treated rats in which BLA-evoked firing was attenuated by these treatments. A, Treat- mentwithAMPH(0.5mg/kg,i.v.)attenuatesBLA-evokedfiringincontrols(n 9cells,9rats), but this effect was not statistically reliable in rats receiving repeated AMPH treatments (n 8 cells, 8 rats). B, Treatment with the D1 receptor agonist <t>SKF81297</t> (0.5 mg/kg, i.v.) also atten- uated BLA-evoked firing in control rats but not in AMPH-treated rats suggesting that these treatments induce a disruption in D1 receptor function (n 6 cells, 6 rats per group). C, Sup- pression of evoked-firing induced by VTA burst stimulation did not differ between saline- treated (n 6 cells, 4 rats) and AMPH-treated (n 7 cells, 7 rats) animals.
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    Figure 6. Changes in BLA-evoked firing induced by DA agonists and VTA stimulation. Left panelsrepresentmean SEMevokedfiringprobabilityunderbaselineconditions(whitebars) and after treatment with DA agonists/VTA stimulation (gray bars); p 0.05, difference relative to baseline. Right panels display the proportion of neurons recorded from saline- and AMPH-treated rats in which BLA-evoked firing was attenuated by these treatments. A, Treat- mentwithAMPH(0.5mg/kg,i.v.)attenuatesBLA-evokedfiringincontrols(n 9cells,9rats), but this effect was not statistically reliable in rats receiving repeated AMPH treatments (n 8 cells, 8 rats). B, Treatment with the D1 receptor agonist SKF81297 (0.5 mg/kg, i.v.) also atten- uated BLA-evoked firing in control rats but not in AMPH-treated rats suggesting that these treatments induce a disruption in D1 receptor function (n 6 cells, 6 rats per group). C, Sup- pression of evoked-firing induced by VTA burst stimulation did not differ between saline- treated (n 6 cells, 4 rats) and AMPH-treated (n 7 cells, 7 rats) animals.

    Journal: Journal of Neuroscience

    Article Title: Repeated Amphetamine Exposure Disrupts Dopaminergic Modulation of Amygdala-Prefrontal Circuitry and Cognitive/Emotional Functioning

    doi: 10.1523/jneurosci.1810-11.2011

    Figure Lengend Snippet: Figure 6. Changes in BLA-evoked firing induced by DA agonists and VTA stimulation. Left panelsrepresentmean SEMevokedfiringprobabilityunderbaselineconditions(whitebars) and after treatment with DA agonists/VTA stimulation (gray bars); p 0.05, difference relative to baseline. Right panels display the proportion of neurons recorded from saline- and AMPH-treated rats in which BLA-evoked firing was attenuated by these treatments. A, Treat- mentwithAMPH(0.5mg/kg,i.v.)attenuatesBLA-evokedfiringincontrols(n 9cells,9rats), but this effect was not statistically reliable in rats receiving repeated AMPH treatments (n 8 cells, 8 rats). B, Treatment with the D1 receptor agonist SKF81297 (0.5 mg/kg, i.v.) also atten- uated BLA-evoked firing in control rats but not in AMPH-treated rats suggesting that these treatments induce a disruption in D1 receptor function (n 6 cells, 6 rats per group). C, Sup- pression of evoked-firing induced by VTA burst stimulation did not differ between saline- treated (n 6 cells, 4 rats) and AMPH-treated (n 7 cells, 7 rats) animals.

    Article Snippet: In addition, we tested the effects of the selective D2 agonist bromocriptine (0.5 mg/kg; Sigma-Aldrich) and the selective D4 agonist PD 168,077 (N-[[4-(2cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide) (1.0 mg/kg; Tocris Biosciences) on BLA-evoked inhibition, and the selective D1 receptor agonist SKF81297 (6-chloro-2,3,4,5-tetrahydro-1-phenyl-1 H3-benzazepine hydrobromide) (0.5 mg/kg; Tocris Biosciences) on BLAevoked excitatory responses.

    Techniques: Saline, Control, Disruption

    Figure 7. Representative PSTH illustrating the effect of D1 receptor stimulation on BLA 3 PFC()incontrolandAMPH-treatedrats.Eachhistogramiscompiledfromfiringdataobtained over 40 single-pulse stimulations of the BLA. Stimulation of D1 receptors with SKF81297 re- duced spike firing evoked by BLA stimulation in a neuron recorded from a saline-treated rat (top). However, similar treatments were ineffective at altering BLA-evoked firing in a rat that had received repeated AMPH (bottom).

    Journal: Journal of Neuroscience

    Article Title: Repeated Amphetamine Exposure Disrupts Dopaminergic Modulation of Amygdala-Prefrontal Circuitry and Cognitive/Emotional Functioning

    doi: 10.1523/jneurosci.1810-11.2011

    Figure Lengend Snippet: Figure 7. Representative PSTH illustrating the effect of D1 receptor stimulation on BLA 3 PFC()incontrolandAMPH-treatedrats.Eachhistogramiscompiledfromfiringdataobtained over 40 single-pulse stimulations of the BLA. Stimulation of D1 receptors with SKF81297 re- duced spike firing evoked by BLA stimulation in a neuron recorded from a saline-treated rat (top). However, similar treatments were ineffective at altering BLA-evoked firing in a rat that had received repeated AMPH (bottom).

    Article Snippet: In addition, we tested the effects of the selective D2 agonist bromocriptine (0.5 mg/kg; Sigma-Aldrich) and the selective D4 agonist PD 168,077 (N-[[4-(2cyanophenyl)piperazin-1-yl]methyl]-3-methylbenzamide) (1.0 mg/kg; Tocris Biosciences) on BLA-evoked inhibition, and the selective D1 receptor agonist SKF81297 (6-chloro-2,3,4,5-tetrahydro-1-phenyl-1 H3-benzazepine hydrobromide) (0.5 mg/kg; Tocris Biosciences) on BLAevoked excitatory responses.

    Techniques: Saline